Delayed reepithelialization and basement membrane regeneration after wounding in mice lacking CXCR3
نویسندگان
چکیده
منابع مشابه
Delayed liver regeneration in mice lacking liver serum response factor.
Various immediate early genes (IEGs) upregulated during the early process of liver regeneration are transcriptional targets of the serum response factor (SRF). We show here that the expression of SRF is rapidly induced in rodent liver after partial hepatectomy. Because the inactivation of the SRF gene in mice is embryonic lethal, the in vivo role of SRF in liver regeneration after partial hepat...
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The CXC chemokine receptor 3 (CXCR3) has been linked to autoimmune and inflammatory disease, allograft rejection, and ischemic nephropathy. CXCR3 is expressed on endothelial and smooth muscle cells. Although a recent study posited that antagonizing of CXCR3 function may reduce atherosclerosis, the role of CXCR3 in controlling physiological vascular functions remains unclear. This study demonstr...
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We previously demonstrated that adiponectin has anti-fibrogenic and anti-inflammatory effects in the liver of mouse models of various liver diseases. However, its role in liver regeneration remains unclear. The aim of this study was to determine the role of adiponectin in liver regeneration. We assessed liver regeneration after partial hepatectomy in wild-type (WT) and adiponectin knockout (KO)...
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objective: patients over 60 years of age have higher mortality and morbidity after major liver resections. nitric oxide (no) derived from the catalytic activity of nos2 plays a beneficial role in liver regeneration (lr) after partial hepatectomy (ph). in this experiment, we evaluated the effect of nos2 knockout (ko) on lr in aged mice after ph. materials and methods: in this cohort study, 52 tw...
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ژورنال
عنوان ژورنال: Wound Repair and Regeneration
سال: 2009
ISSN: 1067-1927,1524-475X
DOI: 10.1111/j.1524-475x.2008.00439.x